Some
interfaces support "multi client". If they don't and you use high quality music
editing software which tend to use exclusive mode for the sound drivers then you
won't get the screen reader and music out through the same channel. You'll then
likely have to get a cheap analogue mixer to mix the two together to get them
out through the same headphones or speakers.
I don't know if the USB
cable quality would matter though. They should all preserve digital
accuracy.
I would see if any of
them have a digital volume limiter to avoid getting the eardrums blasted by
unpredictable volume levels as is often the case with youtube. This is best done
in digital in the PC software or by the device if that's an actual thing any of
them do.
I'm also
really interested in cutting down on the electro-magnetic interference. That
leads into investigations of using optocouplers and questions of how to power
them, so USB batteries, 5v solar panels or super effectively screened power
supplies.
Does any one
have an interest in EMF, whether for sound quality or
health?