That depends on how, exactly, you define "would function with an Apple Macintosh."  I do not know of a version of NVDA that is designed to run under OS X proper (much like JAWS, ZoomText [if you want the Reader-Magnifier version], and Window Eyes).  However, if one installs a virtual Windows environment on a Mac you can run Windows-based software on the machine and be able to "flip-flop" easily between the virtual Windows environment and native OS X environment via Mission Control.

          Wine is one of the most commonly used virtual Windows environments, there are many others, and there's even WineBottler which allows you to tuck Windows applications into the OS X environment.


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