I seem to remember a discussion on WEB AIM where links that have off-screen text for their label don't work with NVDA and a specific browser. I don't remember if it was chrome or firefox. Essential HTML code:
<a ref="someplace" class="icon reply font"><span class="SROnly">Reply</span></a>
Any chance you could get the results of NVDA-F1 and/or the results of jaws-co then I could probably tell if your link is coded this way.