Having or not having an optical drive (DVD/CD) really has no bearing on it since you are booting either from a HDD or SSD [unless you have a very idiosyncratic system the like of which I've never encountered]. In any case, I recommend that Fast Startup be turned off, period, for reasons I mentioned earlier.
Brian - Windows 10 Home, 64-Bit, Version 1809, Build 17763
A great deal of intelligence can be invested in ignorance when the need for illusion is deep.
~ Saul Bellow, To Jerusalem and Back