Ask about using iTunes with NVDA


Hello listers, 
I have to back up my iPhone to my computer using iTunes and NVDA but I've never done it before. So, I've the following questions. 
1. Is it totally accessible to use iTunes with NVDA to back up iPhone without sighted assistant? 
2. Is it possible to change back up storage from C: to D: or any external drive? I'm afraid that my C: doesn't have enough space. 
3. If it's possible, anyone please explain me step by step of how to do it or point me to the link containing tutourial someone already demonstrate it before. 
Thank you. 

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