Just remember that the keyboard commands for the New Chromium-based Edge will be almost precisely the same as they are for the Google Chrome browser, as both are based on the same code.
There were a number of "Old Edge only" things that will disappear. Since I very seldom used original Edge with a screen reader I can't give any more detail than that.
Brian - Windows 10 Pro, 64-Bit, Version 1909, Build 18363
Most of the change we think we see in life is due to truths being in and out of favor.
~ Robert Frost, The Black Cottage (1914)