I used Open Office Calc (their version of Excel) for years with quite a bit of success with NVDA.

People say that LibreOffice is better now, and I can not comment on that since I haven't used it, but OOo was fine for my spreadsheet needs for a very long time.
I never had problems opening spreadsheets from other sources.

Without knowing more about how you use spreadsheets, it's hard to say whether what you want to do can be done accessibly, but the nice thing is that their both free, so you can play with each.

Because I needed better word processing, I bought a recycled office 2019 key early last year for around $25, but if spreadsheets were my only concern, I would have remained with OpenOffice.

Luke