On Fri, Jul 17, 2020 at 09:18 AM, David Kingsbury wrote:

when she hits Control Alt N to open NVDA, nothing happens. Same thing with hitting Control Alt J to open JAWS.

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Please have a read through the topic, Control Alt J Not Working to Open JAWS, on the JAWS Group, for those other than Mr. Kingsbury, who also started that topic there.  It appears that there is at least a decent chance that this has something to do with a JAWS 2020 bug.  This is just too "sudden onset" and screwing up too many desktop shortcuts to be a coincidence.

Of course, if you don't also have JAWS, that's a data point worth noting.
 
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Brian - Windows 10 Pro, 64-Bit, Version 1909, Build 18363  

Science has become just another voice in the room; it has lost its platform.  Now, you simply declare your own truth.

      ~ Dr. Paul A. Offit, in New York Times article, How Anti-Vaccine Sentiment Took Hold in the United States, September 23, 2019