What do you mean by "and make it autorun"?
If you're looking to have NVDA start up when Windows starts up, it makes very little sense to go with portable rather than installed.
You can, of course, create Startup entries to fire up anything under Windows, but it's really "going around Jake's barn" as the saying goes in the Shenandoah Valley to do this with a program that can handle it all if installed.
Brian - Windows 10 Pro, 64-Bit, Version 2004, Build 19041
It’s hard waking up and realizing it’s not always black and white.
~ Kelley Boorn