An uninstall, system restart, and reinstall, choosing the option to create a desktop shortcut/keyboard shortcut, is likely your best option.
This often cures a multitude of sins, and not just with NVDA. And it's easy to do as well.
Brian - Windows 10 Pro, 64-Bit, Version 2004, Build 19041
If you think that you can think about a thing, inextricably attached to something else, without thinking of the thing it is attached to, then you have a legal mind.
~ Thomas Reed Powell