Have you tried:  The Most Basic Troubleshooting Steps for Suspected NVDA Issues

Just doing the three things there, in order, can get you a lot of information about what the potential root cause might be, if not outright solve the issue.

If you have Fast Startup enabled on your system, then make certain to use the Restart option under Power Options to restart your machine, as that's the only way to get Windows 10 to reload from scratch from disk, which is what you want.
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Brian - Windows 10 Pro, 64-Bit, Version 20H2, Build 19042  

Any idiot can face a crisis. It's the day-to-day living that wears you out.

      ~ Anton Chekhov