Jimmy originally offered, "When I turn the speaker back on and it reconnects, NVDA is closed and I need do the control alt n shortcut."
The way I'm reading this is that it's not a typical complaint about "the usual Bluetooth sleeping issues" but that NVDA itself is closing unexpectedly and must be restarted using the keyboard shortcut to fire it up (though one could, of course, fire it up via any method of one's choosing).
Now, if Mr. Vonderlinden would clarify, that would help a lot.
Brian - Windows 10 Pro, 64-Bit, Version 20H2, Build 19042
Always remember others may hate you but those who hate you don't win unless you hate them. And then you destroy yourself.
~ Richard M. Nixon