I am using NVDA 2020.4 with windows 19041.1052 with the latest version of Google Chrome.
From few days, I have noticed a bug in NVDA that, NVDA is completely inaccessible with Chrome. There is no spoken feedback while using Chrome.
Also, in places like D drive or desktop and apps like Notepad, NVDA doesn't respond to alt+ space or application key. Basically, NVDA doesn't speak while navigating through options that appear.