I just installed RC2 of 2022.1.
Upon focusing the Start button, NVDA says nothing and goes silent.
In addition, if I shift+Tab back to the desktop listview of icons, it says nothing, but focus indeed moves between them.
Highlighting an icon and right-clicking it for a menu still has NVDA silent.
RC1 did not do this on my HP DQ1038WM with the Intel(R) Core(TM) i3-1005G1 CPU @ 1.20GHz, 1201 Mhz, 2 Core(s), 4 Logical Processor(s).
But when I then focus back onto the taskbar/notification area,
NvDA starts talking again, as if nothing was wrong.