A couple of weeks back, I reported a problem with NVDA losing speech while scrolling through my gmail list.  I've since installed 2022.1RC2, and tweaked some profile settings for Chrome specifically.  I can now report that, when I lose speech, and have to alt-tab away and back to regain it, NVDA changes from my chrome profile to my generic profile.  I can tell because my speech rates differ between these two profiles.