I also have encountered such kind of issues.
I tried few Things, hope it will solve your problem.
1: if you are trying to click on clickable buttons / dialog
box / menu items, try to press insert / your nvda key + numpad
5 to took your mouse cursor on the point where your nvda
cursor is present.
then, press insert+ enter. it will say activated.
note: these things are from laptop layout.
2: if you are trying to open any link, try taking arro on
that link, and press enter. if click do not happen, simply
press up arro, and after K to get again cursor to your link
and then press enter.
3: if you are facing issue with dialog box, then after
enter, try pressing control+ home / control+ end key to reach
top / end of the page. there you will find clickable dialog.
click on it, it will show you the dialog.
Now a days, these kinds of dialogs are found on lot's of
if these things do not work, then 95% that website
accessibility has some issues.
you may find such issues in menu items, or date filling